Preferred Label : Anti-Ly6E Antibody-Drug Conjugate RG 7841;
NCIt synonyms : ADC DLYE5953A; Anti-LY6E-VCMMAE;
NCIt related terms : RG-7841; Anti-Ly6E Antibody-Drug Conjugate DLYE5953A;
NCIt definition : An antibody-drug conjugate (ADC) composed of an antibody against the tumor-associated
antigen (TAA) lymphocyte antigen 6 complex locus E (Ly6E) and linked to an as of yet
undisclosed cytotoxic agent, with potential antineoplastic activity. Upon intravenous
administration, the antibody moiety of RG 7841 targets and binds to Ly6E expressed
on tumor cells. Upon binding and internalization, the cytotoxic agent is released
and kills, through an as of yet unknown mechanism of action, the Ly6E-expressing cancer
cells. Ly6E, an interferon (IFN)-inducible glycosylphosphatidylinositol (GPI)-linked
cell membrane protein, is expressed on a variety of tumor cell types.;
UNII : ONS92I2A7F;
Molecule name : DLYE5953A; RG-7841; RG 7841;
NCI Metathesaurus CUI : CL473919;
Origin ID : C116745;
UMLS CUI : C5203797;
Semantic type(s)
- concept_is_in_subset
- has_target
