Nucleoside Analog DFP-10917

Preferred Label : Nucleoside Analog DFP-10917;

NCIt synonyms : 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine;

NCIt definition : A deoxycytosine analog with potential antineoplastic activity. Upon administration, DFP-10917 is phosphorylated to generate its nucleotide form that functions as a deoxycytosine mimic and is incorporated into DNA in tumor cells. This causes DNA strand breaks during polymerization due to beta-elimination during the fidelity checkpoint, which results in G2/M phase-arrest and tumor cell apoptosis.;

Molecule name : DFP-10917;

Details

Origin ID

C116744;

UMLS CUI

C3896877;

Automatic exact mappings (from CISMeF team)
- 2'-cyano-2'-deoxyarabinofuranosylcytosine [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- DFP-10917 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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