Preferred Label : Anti-ETBR/MMAE Antibody-Drug Conjugate DEDN6526A;
NCIt synonyms : ADC DEDN6526A;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin (Ig) G1 monoclonal
antibody against anti-endothelin B receptor (ETBR) and covalently linked to monomethyl
auristatin E (MMAE), an auristatin derivative and a potent microtubule disrupting
agent, with potential antineoplastic activity. Upon administration, the monoclonal
antibody moiety of DEDN6526A binds to ETBR-expressing tumor cells and is internalized,
thereby delivering MMAE intracellularly. Proteolytic cleavage releases MMAE, which
then binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest
and tumor cell apoptosis. ETBR, a G-protein coupled receptor that can activate RAF/MEK
signaling, is overexpressed in a variety of tumor cell types and plays a key role
in tumor cell proliferation, invasion, epithelial-mesenchymal transition (EMT) and
angiogenesis.;
Molecule name : DEDN6526A;
NCI Metathesaurus CUI : CL433966;
Origin ID : C116742;
UMLS CUI : C3896878;
Semantic type(s)
- concept_is_in_subset
- has_target
