Thymidylate Synthase Inhibitor DFP-11207

Preferred Label : Thymidylate Synthase Inhibitor DFP-11207;

NCIt synonyms : TS Inhibitor DFP-11207;

NCIt related terms : DFP-11207;

NCIt definition : An orally available thymidylate synthase (TS) inhibitor with potential antineoplastic activity. Upon oral administration, DFP-11207 binds to and inhibits TS. This reduces thymine nucleotide synthesis, inhibits DNA synthesis and cell division, causes DNA damage and leads to tumor cell apoptosis. TS catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP).;

UNII : 33RN5G108E;

CAS number : 1296177-16-6;

Molecule name : DFP-11207;

NCI Metathesaurus CUI : CL473914;

Details

Origin ID

C116720;

UMLS CUI

C3896876;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- DFP-11207 [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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