Preferred Label : Thymidylate Synthase Inhibitor DFP-11207;
NCIt synonyms : TS Inhibitor DFP-11207;
NCIt related terms : DFP-11207;
NCIt definition : An orally available thymidylate synthase (TS) inhibitor with potential antineoplastic
activity. Upon oral administration, DFP-11207 binds to and inhibits TS. This reduces
thymine nucleotide synthesis, inhibits DNA synthesis and cell division, causes DNA
damage and leads to tumor cell apoptosis. TS catalyzes the conversion of deoxyuridine
monophosphate (dUMP) to deoxythymidine monophosphate (dTMP).;
UNII : 33RN5G108E;
CAS number : 1296177-16-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1296177-16-6
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G-SRS /a ;
Molecule name : DFP-11207;
NCI Metathesaurus CUI : CL473914;
Origin ID : C116720;
UMLS CUI : C3896876;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
