Preferred Label : Topical Keratin;
NCIt definition : A topical formulation containing the naturally-derived biomaterial keratin that has
wound repair promoting, hemostatic, moisturizing and potential radioprotective activities.
Upon topical application to an injured site, keratin adheres to the injured tissue,
and forms an extracellular matrix that mimics the structure and function of the native
tissue. This exogenous extracellular matrix is able to absorb fluid, accelerate thrombus
formation through beta1 integrin-mediated platelet adhesion and forms a physical seal
on the wound. This facilitates tissue regeneration by promoting cellular proliferation
and migration, reducing pro-inflammatory cytokine and chemokine expression and altering
the expression of extracellular matrix components and adhesion molecules. Altogether,
this promotes wound healing and provides protection from damage due to thermal or
radiation exposure. Keratin is an essential component in nails, hair and skin.;
Drug name : KeraStat;
NCI Metathesaurus CUI : CL473913;
Origin ID : C116717;
UMLS CUI : C3897354;
Semantic type(s)
- concept_is_in_subset
