Preferred Label : Carbon C 13 Acetate;
NCIt synonyms : 1,2-13C Acetate; 2-13C Acetate;
NCIt definition : The non-radioactive naturally occurring isotope of acetate, carbon C 13 acetate, with
potential use for metabolic tumor imaging upon nuclear magnetic resonance (NMR) spectroscopy.
Upon infusion, carbon C 13 acetate is taken up by cancer cells and is utilized by
metabolic pathways in the tumor cell. Specifically, the tumor cells oxidize acetate,
in the form of acetyl coenzyme A (acetyl-CoA), in the citric acid cycle. Upon 13C-NMR,
the metabolic phenotype of a tumor can be assessed. Certain alternative metabolic
pathways are activated in tumor cells and use substrates other than glucose, such
as acetate, for acetyl-CoA production.;
NCI Metathesaurus CUI : CL473910;
Origin ID : C116714;
UMLS CUI : C3899708;
Semantic type(s)
- concept_is_in_subset
