Ethaselen - CISMeF

Preferred Label : Ethaselen;

NCIt synonyms : BBSKE; 1, 2-[Bis (1, 2-Benzisoselenazolone-3 (2H) -Ketone)] Ethane;

NCIt definition : An orally bioavailable organoselenium inhibitor of thioredoxin reductase 1 (TrxR1), with potential antineoplastic activity. Upon oral administration, ethaselen specifically binds to the selenocysteine-cysteine redox pair in the C-terminal active site of TrxR1 and inhibits its activity, which may result in growth inhibition and the induction of apoptosis in TrxR1 overexpressing tumor cells. TrxR1, upregulated in many cancer cell types, plays a key role in various redox-dependent cellular pathways, regulates transcription factor activity, inhibits apoptosis, and promotes cell growth and survival.;

UNII : 4Q2EZS1IWG;

CAS number : 217798-39-5;

Details

Origin ID

C116713;

UMLS CUI

C1312515;

Currated CISMeF NLP mapping
- (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane [MeSH Supplementary Concept]
- (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane [MeSH Supplementary Concept]
- (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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