NCIt synonyms : DNA Plasmid Encoding Interleukin-12 INO-9012;
NCIt definition : A plasmid DNA vaccine encoding the human pro-inflammatory cytokine interleukin-12
(IL-12) with potential immunoactivating activity. Upon intramuscular delivery by electroporation
of rocakinogene sifuplasmid, IL-12 is translated in cells and activates the immune
system by promoting the activation of natural killer cells (NK cells), inducing secretion
of interferon-gamma and promoting cytotoxic T-cell responses against tumor cells.
This may result in both immune-mediated tumor cell death and the inhibition of tumor
cell proliferation.;
UNII : 91JHE0ANN8;
CAS number : 2253753-17-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2253753-17-0
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Currated CISMeF NLP mapping