NCIt synonyms : DNA Plasmid Encoding Interleukin-12 INO-9012;
NCIt definition : A plasmid DNA vaccine encoding the human pro-inflammatory cytokine interleukin-12
(IL-12) with potential immunoactivating activity. Upon intramuscular delivery by electroporation
of rocakinogene sifuplasmid, IL-12 is translated in cells and activates the immune
system by promoting the activation of natural killer cells (NK cells), inducing secretion
of interferon-gamma and promoting cytotoxic T-cell responses against tumor cells.
This may result in both immune-mediated tumor cell death and the inhibition of tumor
cell proliferation.;
Currated CISMeF NLP mapping