2-Deoxy-D-glucose

Preferred Label : 2-Deoxy-D-glucose;

NCIt synonyms : 2-DG; Deoxyglucose;

NCIt related terms : 2-DEOXYGLUCOSE;

NCIt definition : A non-metabolizable glucose analog in which the hydroxyl group at position 2 of glucose is replaced by hydrogen, with potential glycolysis inhibiting and antineoplastic activities. Although the exact mechanism of action has yet to be fully elucidated, upon administration of 2-deoxy-D-glucose (2-DG), this agent competes with glucose for uptake by proliferating cells, such as tumor cells. 2-DG inhibits the first step of glycolysis and therefore prevents cellular energy production, which may result in decreased tumor cell proliferation.;

UNII : 9G2MP84A8W;

CAS number : 154-17-6;

Details

Origin ID

C116618;

UMLS CUI

C4049845;

Automatic exact mappings (from CISMeF team)
- 2-deoxy-d-glucose [Substance BNPC]
- deoxyglucose [MeSH concept]
- deoxyglucose [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- 2-deoxy-d-glucose [Substance BNPC]
- deoxyglucose [MeSH Descriptor]
- deoxyglucose [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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