Preferred Label : Mitozolomide;
NCIt synonyms : imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-chloroethyl)-3,4-dihydro-4-oxo;
NCIt related terms : Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-chloroethyl)-3,4-dihydro-4-oxo-; Azolastone;
NCIt definition : A prodrug of imidazotetrazine alkylating agent with antineoplastic property. Mitozolomide
undergoes ring opening upon the nucleophilic attack at C-4 by an activated molecule
of water within the major groove of DNA. The resulting bioactive mono-alkyltriazene
species are capable of alkylating nucleophilic residues in the immediate vicinity
such as N-7 and/or O-6 sites of guanine, thereby causes intra- or inter-stranded DNA
cross-links and trigger apoptosis.;
UNII : E3U7286V3W;
InChIKey : QXYYYPFGTSJXNS-UHFFFAOYSA-N;
CAS number : 85622-95-3;
Drug name : Azolastone;
Chemical formula : C7H7ClN6O2;
NSC code : 353451;
Codes from synonyms : NSC0353451;
Origin ID : C1166;
UMLS CUI : C0066618;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
