Vactosertib - CISMeF

Preferred Label : Vactosertib;

NCIt synonyms : TGFBR1 Inhibitor TEW-7197;

NCIt definition : An orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potential antineoplastic activity. Upon oral administration, vactosertib inhibits the activity of TGFBR1 and prevents TGF-beta/TGFBR1-mediated signaling. This suppresses tumor growth in TGFBR1-overexpressing tumor cells. TGFBR1, which is overexpressed in a variety of tumor cell types, plays a key role in tumor cell proliferation. Expression of TGF-beta promotes tumor cell proliferation, enhances the migration of tumor cells and suppresses the response of the host immune system to tumor cells.;

UNII : 6T4O391P5Y;

InChIKey : FJCDSQATIJKQKA-UHFFFAOYSA-N;

CAS number : 1352608-82-2;

Molecule name : TEW-7197;

NCI Metathesaurus CUI : CL473674;

Details

Origin ID

C116357;

UMLS CUI

C4682399;

Currated CISMeF NLP mapping
- vactosertib [MeSH Supplementary Concept]
- vactosertib [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- vactosertib [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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