Preferred Label : Fluorine F 18-AV-133;
Obsolete resource : true;
NCIt synonyms : (2R,3R,11bR)-9-(3-18F-fluoropropoxy)-3-isobutyl-10-methoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol; 18F-FP-DTBZ; 9-[18F]Fluoropropyl-( )-dihydrotetrabenazine; 18F-FP-( )-DTBZ; 18F-AV-133;
NCIt definition : A radioconjugate composed of the vesicular monoamine transporter 2 (VMAT2) targeting
agent AV-133, a dihydrotetrabenazine analog, labeled with the positron-emitting isotope
fluorine F 18, that can potentially be used as a tracer using positron emitting tomography
(PET) imaging. Upon administration, the AV-133 moiety of fluorine F 18-AV-133 binds
to VMATs expressed on monoamine neurons and pancreatic beta-cells within the islets
of Langerhans. Upon PET imaging, VMAT2-expressing cells can be detected and the level
of functional monoamine neurons can be assessed, which can be used in the diagnosis
of neurodegenerative diseases. In addition, this radiotracer can be used to assess
the function of pancreatic beta-cells. VMAT2, a transporter that loads monoamine neurotransmitters
into secretory vesicles, is expressed on biogenic amine-containing neurons in the
central nervous system (CNS) and pancreatic beta cells.;
NCIt note : See 'Florbenazine F-18(C171883)';
Concept status : Retired_Concept;
Origin ID : C116356;
UMLS CUI : C2934037;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
