Preferred Label : siRNA-transfected Peripheral Blood Mononuclear Cells APN401;
NCIt synonyms : siRNA-transfected PBMC APN401;
NCIt definition : Autologous peripheral blood mononuclear cells (PBMCs) transfected ex vivo with small-interfering
ribonucleic acid (siRNA) directed against the E3 ubiquitin ligase casitas B-lineage
lymphoma-b gene (Cbl-b), with potential immunoactivating and antineoplastic activities.
The Cbl-b gene is silenced ex vivo through the binding of Cbl-b siRNA to Cbl-b mRNA,
which prevents the translation of the Cbl-b protein in T-lymphocytes. Upon infusion,
the activated, Cbl-b-silenced T-lymphocytes are able to increase the production of
cytokines, proliferate and activate the immune system, which leads to cancer cell
eradication. Cbl-b, a negative regulator of the immune system, is mutated in a variety
of cancer cell types. Its expression is inversely correlated with activation of T-lymphocytes
and tumor cell eradication.;
Molecule name : APN401;
NCI Metathesaurus CUI : CL473671;
Origin ID : C116353;
UMLS CUI : C3896917;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
