Preferred Label : PI3K/mTORC1/mTORC2 Inhibitor DCBCI0901;
NCIt definition : An inhibitor of phosphatidylinositide 3-kinase (PI3K), raptor-mTOR (mTOR complex 1
or mTORC1) and rictor-mTOR (mTOR complex 2 or mTORC2) with potential antineoplastic
activity. Upon intravenous infusion, PI3K/mTORC1/mTORC2 inhibitor DCBCI0901 binds
to and inhibits PI3K as well as both mTORC1 and mTORC2, which may result in both apoptosis
and a decrease in cell proliferation in tumor cells overexpressing PI3K, mTORC1, and
mTORC2. Activation of the PI3K/mTOR signaling pathway promotes cell growth, survival,
and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream
of PI3K, may also be activated independent of PI3K.;
Molecule name : DCBCI0901;
NCI Metathesaurus CUI : CL473670;
Origin ID : C116351;
UMLS CUI : C3896882;
Semantic type(s)
- concept_is_in_subset
