Preferred Label : Synthetic Glioblastoma Mutated Tumor-specific Peptides Vaccine Therapy APVAC2;
NCIt definition : A personalized peptide-based cancer vaccine comprised of one or two de novo synthesized
patient-specific tumor-mutated peptides associated with glioblastoma (GB), with potential
immunomodulating and antineoplastic activities. Vaccination with synthetic GB mutated
tumor-specific peptides vaccine therapy APVAC2 stimulates the host immune system to
mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the selected
mutated tumor-associated peptides, which results in decreased GB growth. These peptides
are specifically selected and synthesized based on the expression of the patient's
own mutated tumor-associated antigens, which were detected during individual tumor
genome sequencing.;
Molecule name : APVAC2;
NCI Metathesaurus CUI : CL473666;
Origin ID : C116332;
UMLS CUI : C3896741;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
