Preferred Label : CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine;
NCIt synonyms : CD105/Yb-1/SOX2/CDH3/MDM2 Plasmid Vaccine; STEMVAC Th1 Polyepitope Plasmid-based Vaccine;
NCIt definition : A plasmid DNA vaccine containing the mammalian expression vector pUMVC3 (pNGVL3) encoding
epitopes of CD105 (Endoglin), Y-box binding protein 1 (Yb-1), SRY-box 2 (SOX2), cadherin
3 (CDH3), and murine double minute 2 (MDM2) proteins, with potential immunomodulating
and antineoplastic activities. Upon intradermal administration of pUMVC3-CD105/Yb-1/SOX2/CDH3/MDM2-epitopes
plasmid DNA vaccine, the plasmid transfects cells and the peptides are expressed.
This generates a specific memory Th1 (T-helper) cell immune response, stimulates secretion
of cytokines by the T cells and leads to a cytotoxic T-lymphocyte (CTL) response against
CD105/Yb-1/SOX2/CDH3/MDM2-expressing tumor cells. CD105/Yb-1/SOX2/CDH3/MDM2 proteins
are highly immunogenic tumor associated antigens that are overexpressed in breast
cancer. Additionally, these antigens are associated with breast cancer stem cells
and with epithelial to mesenchymal transformation (EMT).;
Molecule name : STEMVAC;
NCI Metathesaurus CUI : CL473655;
Origin ID : C116321;
UMLS CUI : C3896764;
Semantic type(s)
- concept_is_in_subset
