Metoprine - CISMeF

Preferred Label : Metoprine;

NCIt synonyms : DDMP;

NCIt related terms : BW 197U;

NCIt definition : A diaminopyrimidine folate antagonist with potential antineoplastic activity. Metoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism and cell growth; it also inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble metoprine is capable of crossing the blood-brain barrier. (NCI04);

UNII : 2L9RKX796Q;

InChIKey : VQJHOPSWBGJHQS-UHFFFAOYSA-N;

CAS number : 7761-45-7;

Molecule name : BW 197U;

Chemical formula : C11H10Cl2N4;

NSC code : 19494; 7364;

Codes from synonyms : NSC0007364;

Details

Origin ID

C1161;

UMLS CUI

C0066142;

Automatic exact mappings (from CISMeF team)
- Metoprine [ICHI extension code]
Currated CISMeF NLP mapping
- Metoprine [ICD-11 Extension code]
- metoprine [MeSH Supplementary Concept]
- metoprine [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Metoprine [ICD-11 Extension code]
- metoprine [MeSH concept]
- metoprine [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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