Preferred Label : Copper Cu 64-DOTA-AE105;
NCIt synonyms : 64Cu-DOTA-AE105;
NCIt definition : A radiotracer composed of AE105, a urokinase-type plasminogen activator receptor (uPAR)
peptide antagonist, conjugated with DOTA and labeled with the radionuclide copper
Cu 64, with potential imaging activity upon positron emission tomography (PET). Upon
administration, the AE105 moiety of copper Cu 64-DOTA-AE105 targets and binds to uPAR-expressing
tumor cells. Upon PET imaging, the copper Cu 64 moiety can be visualized, uPAR-expressing
tumor cells can be quantified and the degree of tumor aggressiveness can be assessed.
uPAR expression is correlated with increased tumor invasiveness and aggressiveness
as well as a poor prognosis.;
NCI Metathesaurus CUI : CL473493;
Origin ID : C116075;
UMLS CUI : C3899497;
Semantic type(s)
- concept_is_in_subset
