Preferred Label : Iodine I 124 CPD-1028;
NCIt synonyms : [I-124]-CPD-1028;
NCIt definition : A radioconjugate composed of the insulin-like growth factor 1 receptor (IGF-1R) binding
agent CPD-1028 and conjugated to the radionuclide iodine I 124, with potential tumor
imaging upon positron emission tomography/computed tomography (PET/CT). Upon administration,
iodine I 124 CPD-1028 targets and binds to IGF-1R-expressing tumor cells. Upon PET/CT
imaging, the iodine I 124 moiety can be visualized and the quantity of IGF-1R-expressing
tumor cells can be assessed. IGF-1R, a receptor tyrosine kinase overexpressed in a
variety of human cancers, plays a significant role in the stimulation of cellular
proliferation, oncogenic transformation, and the suppression of apoptosis.;
NCI Metathesaurus CUI : CL473490;
Origin ID : C116071;
UMLS CUI : C3898667;
Semantic type(s)
- concept_is_in_subset
