Preferred Label : Lupartumab Amadotin;
NCIt definition : An antibody-drug conjugate (ADC) composed of an antibody against a structural homolog
of the urokinase-type plasminogen activator receptor (uPAR) and tumor-associated antigen,
C4.4a, and conjugated with a cytotoxic agent, with potential antineoplastic activity.
Upon intravenous administration, lupartumab amadotin targets and binds to C4.4a-expressing
tumor cells. Upon binding and cell entry, the cytotoxic agent kills the tumor cell.
C4.4a, a glycolipid-anchored membrane protein and a member of the Ly-6 family, is
overexpressed by a variety of cancer cell types whereas it is minimally expressed
on healthy cells.;
UNII : 21970JMA97;
CAS number : 1640972-00-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1640972-00-4
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : BAY112-9980;
NCI Metathesaurus CUI : CL473489;
Origin ID : C116070;
UMLS CUI : C5235374;
Semantic type(s)
- concept_is_in_subset
