Preferred Label : Liposomal Mitoxantrone Hydrochloride;
NCIt synonyms : Mitoxantrone Hydrochloride Liposome;
NCIt definition : A formulation composed of the hydrochloride salt form of the anthracenedione antibiotic
mitoxantrone encapsulated within liposomes, with potential antineoplastic activity.
Upon intravenous administration, mitoxantrone intercalates into and forms crosslinks
with DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase
II, which both results in DNA strand breaks and prevents DNA synthesis. This leads
to the induction of apoptosis in the rapidly dividing cancer cells. The liposomal
delivery of mitoxantrone improves drug penetration into tumors and decreases drug
clearance, thereby increasing drug circulation and therapeutic efficacy while lowering
the toxic effects.;
NCI Metathesaurus CUI : CL473483;
Origin ID : C116064;
UMLS CUI : C3898587;
Semantic type(s)
- concept_is_in_subset
