TMPRSS2/ETV4 Fusion Gene

Preferred Label : TMPRSS2/ETV4 Fusion Gene;

NCIt synonyms : TMPRSS2-ETV4 Fusion Gene; TMPRSS2::ETV4 Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(17;21)(q21;q22) which fuses the 5' untranslated region of the TMPRSS2 gene upstream of exon 3 of the ETV4 gene. This rearrangement is associated with prostate carcinoma and androgen-dependent expression of this fusion gene results in overexpression of ETS translocation variant 4 protein activity.;

PubMed : 16585160;

Details

Origin ID

C116015;

UMLS CUI

C3897384;

Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
related_to_genetic_biomarker
- ETV4 Gene [NCIt concept]
- TMPRSS2 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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