" /> TMPRSS2/ETV5 Fusion Gene - CISMeF





Preferred Label : TMPRSS2/ETV5 Fusion Gene;

NCIt synonyms : TMPRSS2-ETV5 Fusion Gene; TMPRSS2::ETV5 Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(3;21)(q28;q22) which fuses either the 5' untranslated region or the 5' end including exons 1 and 2 of the TMPRSS2 gene with exon 2 of the ETV5 gene. This rearrangement is associated with prostate carcinoma and androgen-dependent expression of this fusion gene results in overexpression of ETS translocation variant 5 protein activity.;

NCIt note : Fusion proteins may be expressed if exon 2 of the TMPRSS2 gene is present.;

PubMed : 18172298;

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20/08/2025


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