Preferred Label : Indium In 111-DOTA-exendin-4;
NCIt synonyms : 111In-DOTA-exendin-4; [Lys40(Ahx-DOTA-111In)NH2]-exendin-4;
NCIt definition : A radiopharmaceutical composed of the glucagon-like peptide 1 receptor (GLP-1R) agonist
exendin-4 linked by the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic
acid (DOTA) to the positron-emitting radionuclide indium In 111, with potential use
in diagnostic imaging upon positron emission tomography (PET). Upon administration
of indium In 111-DOTA-exendin-4, the exendin-4 moiety binds to GLP-1R and is subsequently
internalized. The radionuclide moiety can be detected using PET and GLP-1R-expressing
tumors can be localized. GLP-1R, located on beta cells, is overexpressed on insulinomas,
which are insulin-secreting neuroendocrine tumors.;
NCI Metathesaurus CUI : CL473313;
Origin ID : C115981;
UMLS CUI : C3898770;
Semantic type(s)
- concept_is_in_subset
