Preferred Label : Gallium Ga 68-DOTA-exendin-4;
NCIt synonyms : 68Ga-DOTA-exendin-4; [Lys40(Ahx-DOTA-68Ga)NH2]-exendin-4;
NCIt definition : A radiopharmaceutical composed of the glucagon-like peptide 1 receptor (GLP-1R) agonist
exendin-4 linked by the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic
acid (DOTA) to the positron-emitting radionuclide gallium Ga 68, with potential use
in diagnostic imaging upon positron emission tomography (PET). Upon administration
of gallium Ga 68-DOTA-exendin-4, the exendin-4 moiety binds to GLP-1R and is subsequently
internalized. The radionuclide moiety can be detected using PET and GLP-1R-expressing
tumors can be localized. GLP-1R, located on beta cells, is overexpressed on insulinomas,
which are insulin-secreting neuroendocrine tumors.;
NCI Metathesaurus CUI : CL473312;
Origin ID : C115980;
UMLS CUI : C3899045;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
