Preferred Label : Larotrectinib;
NCIt synonyms : 3S)-N-(5-((2R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxypyrrolidine-
1-carboxamide; 1-Pyrrolidinecarboxamide, N-(5-((2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl)pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxy-,
(3S)-;
NCIt definition : An orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic
activity. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk
interaction and Trk activation, which results in both the induction of cellular apoptosis
and the inhibition of cell growth in tumors that overexpress Trk. Trk, a receptor
tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell
types and plays an important role in tumor cell growth and survival.;
UNII : PF9462I9HX;
InChIKey : NYNZQNWKBKUAII-KBXCAEBGSA-N;
CAS number : 1223403-58-4;
Molecule name : ARRY 470; LOXO 101; LOXO-101;
Codes from synonyms : 298;
Origin ID : C115977;
UMLS CUI : C4524315;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
