Preferred Label : Dendritic Cell-targeting Lentiviral Vector ID-LV305;
NCIt synonyms : DCvex-NY-ESO-1;
NCIt definition : An engineered lentiviral vector targeting dendritic cells (DCs) and containing nucleic
acids encoding for the human tumor-associated cancer-testis antigen NY-ESO-1, with
potential immunostimulatory and antineoplastic activities. Upon intradermal administration,
the DC-targeting lentiviral vector ID-LV305 targets and binds to dermal DCs via the
DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) receptor.
Upon internalization of the vector, the NY-ESO-1 protein is expressed, stimulates
DC maturation and activates the immune system to mount a cytotoxic T-lymphocyte (CTL)
response against NY-ESO-1-expressing cells, which may result in tumor cell lysis.
NY-ESO-1 is expressed in normal testes and on the surfaces of various tumor cells,
and plays a key role in tumor cell proliferation and survival.;
Molecule name : ID-LV305;
NCI Metathesaurus CUI : CL473308;
Origin ID : C115976;
UMLS CUI : C3896839;
Semantic type(s)
- concept_is_in_subset
