KMT2B wt Allele

Preferred Label : KMT2B wt Allele;

NCIt synonyms : MLL4 Gene; WBP7; Trithorax, Drosophila, Homolog of, 2 Gene; MLL1B; CXXC10; Myeloid/Lymphoid Or Mixed-Lineage Leukemia 4 Gene; MLL2; KIAA0304; MLL4; Lysine (K)-Specific Methyltransferase 2B wt Allele; TRX2; Mixed Lineage Leukemia Gene Homolog 2 Gene; HRX2; Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) 4 Gene;

NCIt definition : Human KMT2B wild-type allele is located in the vicinity of 19q13.1 and is approximately 21 kb in length. This allele, which encodes histone-lysine N-methyltransferase 2B protein, plays a role in both lysine methylation and the positive regulation of gene transcription.;

NCIt note : The KMT2B/MLL4 gene (EntrezGeneID 9757) was first named MLL2 in the literature; however, MLL2 corresponds to another gene located on chromosome 12 (KMT2D EntrezGeneID 8085). Therefore, KMT2B is often referred to as MLL2 and vice versa in the literature. (UniProt and EntrezGene);

GenBank Accession Number : AJ007041;

Details

Origin ID

C115963;

UMLS CUI

C3889649;

Automatic exact mappings (from CISMeF team)
- Lysine-specific methyltransferase 2b [OMIM gene]
- Lysine-specific methyltransferase 2d [OMIM gene]
- Thioredoxin 2 [OMIM gene]
- lysine methyltransferase 2B [ORDO Gene]
- lysine methyltransferase 2D [ORDO Gene]
OMIM relation
- Lysine-specific methyltransferase 2b [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 19q13.1 [NCIt concept]
gene_is_element_in_pathway
- Lysine Degradation Pathway [NCIt concept]
gene_plays_role_in_process
- Histone Methylation [NCIt concept]
- Methylation [NCIt concept]
- Oogenesis [NCIt concept]
- Ovulation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients