Preferred Label : TLR9 Agonist DUK-CPG-001;
NCIt definition : A synthetic CpG-rich oligonucleotide with potential immunopotentiating activity. TLR9
agonist DUK-CPG-001 binds to and activates intracellular toll-like receptor 9 (TLR9)
in monocytes/macrophages, plasmacytoid dendritic cells (DCs), natural killer (NK)
cells and B-cells. This initiates immune signaling pathways, activates DCs, NK cells
and B-cells, and induces both the production of T-helper 1 cells (Th1) and a Th1-mediated
immune response. TLR9 is a member of the TLR family, which plays a key role in both
pathogen recognition and the activation of innate immunity.;
Molecule name : DUK-CPG-001;
NCI Metathesaurus CUI : CL473296;
Origin ID : C115959;
UMLS CUI : C3896868;
Semantic type(s)
- concept_is_in_subset
- has_target
