Preferred Label : Marcellomycin;
NCIt synonyms : Rhodirubin E; 1-Naphthacenecarboxylic acid, 4-[[O-2,6-dideoxy-alpha-L-lyxo-hexopyranosyl-(1-4)-O-2,
6-dideoxy-alpha-L-lyxo-hexopyranosyl-(1-4)-2,3, 6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy]-2-e
thyl-1,2,3,4,6,11-hexahydro-2,5,7,10-tetrahydroxy-6,11-dioxo-, methyl ester, (1R-(1alpha,2beta,4beta))-
(9CI);
NCIt definition : An antineoplastic oligosaccharide anthracycline antineoplastic antibiotic isolated
from the bacterium Actinosporangium bohemicum. Marcellomycin intercalates into DNA
and induces DNA crosslinks, thereby inhibiting DNA replication and repair and RNA
and protein synthesis. This agent also induces differentiation in HL-60 promyelocytic
leukemia cells by interfering with glycoprotein synthesis. (NCI04);
UNII : 3296X8L13E;
CAS number : 63710-10-1;
NSC code : 265211;
Codes from synonyms : NSC0265211;
Origin ID : C1152;
UMLS CUI : C0065718;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
