Preferred Label : Allogeneic Multivirus-specific Cytotoxic T Lymphocytes;
NCIt synonyms : Allogeneic EBV/CMV/AdV/HHV6/BKV-specific CTLs; Allogeneic Multivirus-specific CTLs;
NCIt definition : A population of closely human leukocyte antigen (HLA)-matched, donor-derived cytotoxic
T lymphocytes (CTLs) that are specifically reactive towards five viruses, Epstein-Barr
virus (EBV), cytomegalovirus (CMV), adenovirus (AdV), human herpesvirus 6 (HHV6),
and human polyomavirus type I (BKV), with potential antiviral activity. Infusion of
the multivirus-specific CTLs into allogeneic hematopoietic stem cell transplant (HSCT)
recipients provides virus-specific cellular immunity and causes specific anti-viral
effects against active viral infections. The administered CTLs also prevent EBV, CMV,
AdV, HHV6, and BKV reactivation and infection as well as inhibiting viral-associated
diseases in immunocompromised patients. The allogeneic multivirus-specific CTLs may
also provide cellular immunity towards the human polyomavirus type II (JC virus; JCV),
which is highly homologous to BKV.;
NCI Metathesaurus CUI : CL472638;
Origin ID : C115107;
UMLS CUI : C3900058;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
