Preferred Label : Dioscorea nipponica Makino Extract DNE3;
NCIt synonyms : Dioscorea nipponica Extract with Ethyl Acetate;
NCIt definition : An extract of the plant Dioscorea nipponica Makino and inhibitor of both the serine/threonine
protein kinase Akt (protein kinase B) and members of the phosphatidylinositol 3-kinase
(PI3K) family of lipid kinases, with potential antineoplastic and anti-metastatic
activities. Dioscorea nipponica Makino extracted with ethyl acetate (DNE3) binds to
and inhibits PI3K and Akt. This inhibits PI3K/Akt-mediated signaling and prevents
both growth and survival of PI3K/Akt-overexpressing tumor cells. In addition, DNE3
increases the expression of tissue inhibitor of metalloproteinase-2 (TIMP-2), inhibits
the secretion of matrix metalloproteinases (MMPs), primarily MMP-2 and MMP-9, and
inhibits the serine protease urokinase (urokinase-type plasminogen activator; u-PA).
This inhibits tumor cell invasion, migration, motility, and adhesion. This agent also
inhibits the activation of both cAMP response element-binding (CREB) and activating
protein-1 (AP-1), and increases the expression of IkappaB (IkB), which inhibits the
activation of nuclear factor-kappa B (NF-kB). These processes further contribute to
this agent's anti-tumor potential in susceptible tumor cells.;
Molecule name : DNE3;
NCI Metathesaurus CUI : CL472634;
Origin ID : C115103;
UMLS CUI : C3896732;
Semantic type(s)
- concept_is_in_subset
