Preferred Label : Anti-CD19/CD3 Tetravalent Antibody AFM11;
NCIt related terms : AFM-11;
NCIt definition : An anti-CD19/anti-CD3 bispecific tetravalent antibody with potential immunostimulatory
and antineoplastic activities. Anti-CD19/CD3 tetravalent antibody AFM11 possesses
two antigen-recognition and binding sites, one for the CD3 complex, a group of T-cell
surface glycoproteins that complex with the T-cell receptor (TCR), and one for CD19,
a tumor-associated antigen (TAA) overexpressed on the surface of B-cells. Upon bolus
infusion of AFM11, this bispecific antibody binds to CD3-expressing T-cells and CD19-expressing
cancer cells, thereby crosslinking CD19-expressing tumor B-cells and cytotoxic T-lymphocytes
(CTLs). This may result in a potent CTL-mediated cell lysis of CD19-expressing B-lymphocytes.
CD19, a B-cell specific membrane antigen, is expressed during both B-cell development
and B-cell malignant growth.;
UNII : UGA95385P3;
CAS number : 250245-29-5;
Molecule name : AFM11;
NCI Metathesaurus CUI : CL472632;
Origin ID : C115101;
UMLS CUI : C3896924;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
