Mannose-Binding Lectin

Preferred Label : Mannose-Binding Lectin;

NCIt synonyms : Mannan-Binding Lectin; Mannose Binding Protein; Recombinant Human Mannose-binding Lectin; MBL; MBP;

NCIt definition : A recombinant protein similar or identical to human mannan-binding lectin (MBL) with opsonin activity. MBL, a soluble pattern recognition receptor (PRR) collectin in the C-type lectin superfamily, is a plasma protein that plays an important role in innate immunity; MBL contains a carbohydrate recognition domain at one end and a collagen-like stalk domain at the other. Upon MBL binding to mannose residues on mannose-containing polysaccharides (mannans) on the surfaces of microorganisms, activation of the complement system results in the deposition of complement components (opsonization) and the clearance of the opsonized microorganisms by phagocytic cells. MBL is part of the mannan-binding lectin pathway (also known as the Ali/Krueger pathway), which has similarities to the classical complement pathway in that activation of C4 and C2 produce activated complement proteins further down the complement cascade. However, unlike the classical complement pathway, activation of this pathway is not antibody dependent.;

Details

Origin ID

C1151;

UMLS CUI

C0065661;

False automatic mappings
- (18F)MBP [MeSH concept]
- mannose-binding lectins [MeSH Descriptor]
See also inter- (CISMeF)
- mannose binding protein A [MeSH Supplementary Concept]
- obsolete mannose binding lectin [GO term]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Mannose-Binding lectin [MeSH concept]
- Mannose-binding protein [LOINC component]
- Mannose-binding protein (substance) [SNOMED CT concept]
- mannose-binding lectin [MeSH Descriptor]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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