Letermovir - CISMeF

Preferred Label : Letermovir;

NCIt synonyms : 2-((4S)-8-Fluoro-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3-(2-methoxy-5-(trifluoromethyl)phenyl)-4H-quinazolin-4-yl)acetic Acid;

NCIt definition : An orally bioavailable, non-nucleoside, 3,4-dihydroquinazolinyl acetic acid and inhibitor of the pUL56 subunit of the viral terminase complex of cytomegalovirus (CMV), with potential CMV-specific antiviral activity. Upon oral administration, letermovir binds to the pUL56 subunit of the viral terminase complex of CMV and prevents the cleavage of concatemeric DNA into monomeric genome length DNA. As this agent interferes with viral DNA processing and subsequent viral DNA packaging into procapsids, CMV replication is blocked and CMV infection is prevented.;

UNII : 1H09Y5WO1F;

InChIKey : FWYSMLBETOMXAG-QHCPKHFHSA-N;

CAS number : 917389-32-3;

Drug name : Prevymis;

Molecule name : AIC246; MK-8228;

Details

Origin ID

C115099;

UMLS CUI

C3852938;

Currated CISMeF NLP mapping
- Letermovir [ICD-11 Extension code]
- Letermovir [LOINC component]
- Letermovir [SMS substance]
- Letermovir (substance) [SNOMED CT concept]
- letermovir [MeSH concept]
- letermovir [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Prevymis [MeSH concept]
- Product containing letermovir (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Letermovir (substance) [SNOMED CT concept]
- Product containing letermovir (medicinal product) [SNOMED CT concept]
- letermovir [MeSH concept]
- letermovir [ATC Code]
- letermovir [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- letermovir [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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