NCIt definition : A synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide
alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely
related to cyclophosphamide, mafosfamide, unlike cyclophosphamide, does not require
hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide; accordingly,
mafosfamide is potentially useful in the intrathecal treatment of neoplastic meningitis.
(NCI04);
Alternative definition : NCI-GLOSS: A form of cyclophosphamide that can be administered as an intrathecal infusion.
Mafosfamide is being studied as an anticancer drug. It belongs to the family of drugs
called alkylating agents.;
UNII : 5970HH9923;
InChIKey : PBUUPFTVAPUWDE-UGZDLDLSSA-N;
CAS number : 88859-04-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 88859-04-5
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