Mafosfamide - CISMeF

Preferred Label : Mafosfamide;

NCIt definition : A synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely related to cyclophosphamide, mafosfamide, unlike cyclophosphamide, does not require hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide; accordingly, mafosfamide is potentially useful in the intrathecal treatment of neoplastic meningitis. (NCI04);

Alternative definition : NCI-GLOSS: A form of cyclophosphamide that can be administered as an intrathecal infusion. Mafosfamide is being studied as an anticancer drug. It belongs to the family of drugs called alkylating agents.;

UNII : 5970HH9923;

InChIKey : PBUUPFTVAPUWDE-UGZDLDLSSA-N;

CAS number : 88859-04-5;

Chemical formula : C9H19Cl2N2O5PS2;

NSC code : 345842;

Codes from synonyms : NSC0345842; CDR0000045350;

Details

Origin ID

C1150;

UMLS CUI

C0065506;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- mafosfamide [MeSH concept]
- mafosfamide [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Cisplatin/Cyclophosphamide/Etoposide/Mafosfamide/Vincristine [NCIt concept]

Keyword's position in hierarchy(ies) :

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