Preferred Label : E-101 Solution;
NCIt definition : An oxidant-generating coupled-enzyme system-based, topical solution comprised of two
enzymes, Aspergillus niger-derived glucose oxidase (GO) and porcine myeloperoxidase
(p-MPO), as well as glucose, sodium chloride and stabilizing amino acids, with potential
broad-spectrum microbicidal activity. Following direct administration of E-101 solution
into the surgical incisional wound via microspray, the enzyme GO converts oxygen into
hydrogen peroxide (H2O2). In turn, p-MPO catalyzes the reaction of H2O2 with hypochlorous
acid (HOCl), which is formed through oxidation of the chloride ion, to generate singlet
oxygen (O2*). As p-MPO binds to microorganisms, O2* is able to exert direct oxidative
damage to microorganisms, resulting in potent antimicrobial activity. E-101 may act
as an anti-bactericidal agent against a variety of microorganisms, including multidrug-resistant
strains. This may prevent infection at the surgical site.;
Molecule name : E-101;
Origin ID : C114986;
UMLS CUI : C3896867;
Semantic type(s)
- concept_is_in_subset
