Preferred Label : Beclabuvir;
NCIt synonyms : (4bS,5aR)-12-Cyclohexyl-N-(dimethylsulfamoyl)-3-methoxy-5a-((3-methyl-3,8-diazabicyclo(3.2.1)oct-8-yl)carbonyl)-4b,5,5a,6-tetrahydrocyclopropa(d)indolo(2,1-a)(2)benzazepine-9-carboxamide;
NCIt definition : A non-nucleoside, polymerase inhibitor of the hepatitis C virus (HCV) nonstructural
protein 5B (NS5B), a RNA-dependent RNA polymerase, with potential activity against
HCV. Upon administration and after intracellular uptake, beclabuvir allosterically
binds to the non-catalytic Thumb 1 site of viral HCV NS5B polymerase and causes a
decrease in viral RNA synthesis and replication. The HCV NS5B protein is essential
for the replication of the viral HCV RNA genome. HCV is a small, enveloped, single-stranded
RNA virus belonging to the Flaviviridae family.;
UNII : MYW1X5CO9S;
InChIKey : ZTTKEBYSXUCBSE-QDFUAKMASA-N;
CAS number : 958002-33-0;
Molecule name : BMS-791325;
Origin ID : C114983;
UMLS CUI : C4045497;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
