NCIt definition : A tumor targeting imaging agent composed of the tumor-specific peptide chlorotoxin
(CTX), a 36-amino acid neurotoxin found in the venom of the Leiurus quinquestriatus
scorpion, linked to the fluorescent dye indocyanine green (ICG), with potential tumor
imaging activity using a near-infrared (NIR) imaging system. Upon intravenous administration
of BLZ-100, the CTX moiety of BLZ-100 specifically binds to and is internalized by
cancer cells of neuroectodermal origin. Using a NIR imaging system, the ICG, which
emits light in the NIR range, permits the intraoperative visualization of tumor cells.
This leads to the clear distinction of healthy tissues from tumor cells, and facilitates
the surgical removal of tumor tissue while sparing normal, healthy cells.;
Currated CISMeF NLP mapping