Preferred Label : Etoposide Toniribate;
NCIt definition : A prodrug of etoposide, a semisynthetic derivative of podophyllotoxin extracted from
the mandrake root Podophyllum peltatum, with potential antineoplastic activity. Upon
intravenous administration of etoposide toniribate, etoposide is released after enzymatic
cleavage of CAP7.1 by specific carboxylesterases (CE) 1 and 2, which are upregulated
in certain tumor cell types. Etoposide acts primarily in the G2 and S phases of the
cell cycle. This drug binds to and inhibits topoisomerase II, an enzyme elevated in
tumor cells. This results in the accumulation of double-strand DNA breaks, the inhibition
of DNA replication and transcription and the induction of apoptotic cell death. The
tumor-specific activation of etoposide increases its efficacy while lowering its systemic
toxicity.;
UNII : A59HL2Q48U;
InChIKey : FCWSQAKOPTZCOD-SQYSSJHTSA-N;
CAS number : 433304-61-1;
Molecule name : CAP7.1; EDO-S7.1;
NCI Metathesaurus CUI : CL472574;
Origin ID : C114977;
UMLS CUI : C5235373;
Semantic type(s)
- concept_is_in_subset
