Preferred Label : Lutetium Lu 177 PP-F11N;
NCIt synonyms : 177Lu-PP-F11N;
NCIt related terms : PP-F11N LUTETIUM LU-177;
NCIt definition : A radioconjugate composed of PP-F11N, a gastrin analog, conjugated to the beta-emitting
radioisotope lutetium Lu 177, with potential antineoplastic activity and potential
use as an imaging agent for scintigraphy. Following intravenous administration, the
PP-F11N moiety binds to the cholecystokinin-2 (CCK-2) receptor. Subsequently, the
CCK-2 receptor-expressing tumor cells can be visualized scintigraphically. In addition,
the radioisotope moiety delivers a cytotoxic dose of beta radiation to CCK-2 receptor-expressing
tumor cells. CCK-2 receptors are expressed on a variety of tumor cell types.;
UNII : 639NVQ0SXF;
CAS number : 1771736-69-6;
NCI Metathesaurus CUI : CL472324;
Origin ID : C114499;
UMLS CUI : C3898564;
Semantic type(s)
- concept_is_in_subset
