Preferred Label : Anagrelide Prolonged-release Formulation;
NCIt synonyms : Anagrelide Retard;
NCIt definition : A prolonged-release tablet formulation containing the quinazoline anagrelide, with
antiplatelet activity. Although the exact mechanism of action through which anagrelide
exerts its effect has yet to be fully elucidated, this agent inhibits the maturation
of megakaryocytes into platelets, which reduces platelet production. Anagrelide also
inhibits cyclic AMP phosphodiesterase III (PDEIII), which prevents PDEIII-mediated
platelet aggregation. This may prevent essential thrombocythemia and thrombosis.;
NCI Metathesaurus CUI : CL472323;
Origin ID : C114497;
UMLS CUI : C3900049;
Semantic type(s)
- concept_is_in_subset
