Preferred Label : 4-Hydroxyestrone;
NCIt synonyms : 4-OHE(1); 3,4-Dihydroxyestra-1,3,5(10)-trien-17-one; 4-OHE1; Estra-1,3,5(10)-trien-17-one, 3,4-dihydroxy-;
NCIt definition : A metabolite formed during the catabolism of estrone by the liver through the hydroxylation
of the carbon at position 4 by cytochrome P450 (CYP) family enzymes, with potential
carcinogenic activity. The mechanism of action for the tumor promoting activity of
4-hydroxyestrone is not known but this metabolic product has increased estrogenic
activity compared to the parent compound. Additionally, oxidation of 4-hydroxyestrone
generates compounds with free radicals that are capable of removing purines from DNA,
which can cause mutagenesis and can lead to tumorigenesis.;
UNII : 3MN57C55S2;
CAS number : 3131-23-5;
Origin ID : C114469;
UMLS CUI : C0048342;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
