Preferred Label : IL-12-expressing Mesenchymal Stem Cell Vaccine GX-051;
NCIt synonyms : MSCs/IL-12M;
NCIt definition : Human mesenchymal stem cells (MSCs) transduced with a retroviral vector encoding a
modified form of the cytokine interleukin-12 (IL-12), with potential immunomodulating
and antineoplastic activities. Upon intratumoral administration, IL-12-expressing
MSC vaccine GX-051 secretes IL-12. IL-12 activates the immune system by both promoting
the secretion of interferon-gamma, which activates natural killer cells (NKs), and
inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation
and increased cell death in tumor cells.;
Molecule name : GX-051;
NCI Metathesaurus CUI : CL471821;
Origin ID : C114385;
UMLS CUI : C3826976;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
