Preferred Label : BH3 Mimetic ABT-737;
NCIt synonyms : Benzamide, 4-(4-((4'-Chloro(1,1'-biphenyl)-2-yl)methyl)-1-piperazinyl)-n-((4-(((1r)-3-(dimethylamino)-1-((phenylthio)methyl)propyl)amino)-3-nitrophenyl)sulfonyl)-;
NCIt related terms : ABT-737;
NCIt definition : An orally bioavailable, selective small molecule B-cell lymphoma 2 (Bcl-2) Homology
3 (BH3) mimetic, with potential pro-apoptotic and antineoplastic activities. ABT-737
binds to the hydrophobic groove of multiple members of the anti-apoptotic Bcl-2 protein
family, including Bcl-2, Bcl-xl and Bcl-w. This inhibits the activity of these pro-survival
proteins and restores apoptotic processes in tumor cells, via activation of Bak/Bax-mediated
apoptosis. The pro-survival Bcl-2 proteins are overexpressed in many cancers and play
important roles in the regulation of apoptosis. Their expression is associated with
increased drug resistance and tumor cell survival. ABT-737 does not inhibit the pro-survival
proteins Mcl-1, Bcl-B, Bfl-1 (A1); therefore, tumors that overexpress these Bcl-2
family proteins are resistant to ABT-737.;
UNII : Z5NFR173NV;
InChIKey : HPLNQCPCUACXLM-PGUFJCEWSA-N;
CAS number : 852808-04-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 852808-04-9
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G-SRS /a ;
Molecule name : ABT-737;
Origin ID : C114384;
UMLS CUI : C1570187;
Semantic type(s)
- UMLS correspondences (same concept)
- ABT-737 [MeSH Supplementary Concept]
- concept_is_in_subset
