Preferred Label : NY-ESO-1(157-165) Peptide-pulsed Autologous Dendritic Cell Vaccine;
NCIt synonyms : Autologous NY-ESO-1 (157-165) Peptide-pulsed DC Vaccine;
NCIt definition : A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with
a peptide derived from the tumor associated antigen human cancer-testis antigen NY-ESO-1
(NY-ESO-1(157-165)), with potential immunostimulatory and antineoplastic activities.
Upon administration, the NY-ESO-1(157-165) peptide-pulsed autologous dendritic cell
vaccine may stimulate the immune system to mount both an anti-tumoral cytotoxic T-lymphocyte
(CTL)- and an antibody-mediated immune response against NY-ESO-1-expressing tumor
cells, which may result in tumor cell lysis. NY-ESO-1 is expressed both in normal
testes and on the surfaces of various tumor cells, and plays a key role in tumor cell
proliferation and survival.;
NCI Metathesaurus CUI : CL471814;
Origin ID : C114380;
UMLS CUI : C3828741;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
