Preferred Label : Copper Cu 64 Plerixafor;
NCIt synonyms : 64-Cu-plerixafor;
NCIt definition : A radioconjugate labeled with the positron-emitting radioisotope, copper Cu 64, and
also composed of plerixafor, a bicyclam and hematopoietic stem cell-mobilizing agent
that targets the chemokine receptor CXCR4, with tumor imaging potential using positron
emission tomography (PET)/computed tomography (CT). Upon administration, the plerixafor
moiety blocks the binding of stromal cell-derived factor-1alpha (SDF-1alpha or CXCL12)
to the cellular receptor CXCR4. In turn, the CXCR4-expressing tumor cells can be visualized
using PET/CT and the resulting images could be used to predict a tumor's response
to certain treatments. The expression of CXCR4 on cancer cells has been correlated
with increased tumor cell survival, tumor progression, and increased metastatic potential.;
NCI Metathesaurus CUI : CL471810;
Origin ID : C114379;
UMLS CUI : C3831008;
Semantic type(s)
- concept_is_in_subset
