Preferred Label : Recombinant Leukoregulin;
NCIt synonyms : Therapeutic Leukoregulin;
NCIt definition : A formulated therapeutic analog of the endogenous lymphokine leukoregulin with potential
antineoplastic activity. Leukoregulin displays direct and indirect cytotoxicity through
tumor cell lysis and enhancing tumor cell susceptibility to natural killer cell-mediated
cytotoxicity. This agent enhances membrane permeability and decreases p-glycoprotein
expression, thereby promoting cytotoxic drug uptake into tumor cells. Leukoregulin
also induces the synthesis of collagenase and hyaluronan, expression and secretion
of interleukin-8, and upregulates stromelysin-1 gene expression in human fibroblasts,
thereby regulating extracellular matrix degradation. (NCI04);
Origin ID : C1143;
UMLS CUI : C1515385;
Semantic type(s)
- concept_is_in_subset
