Preferred Label : Cridanimod Sodium;
NCIt synonyms : Sodium 2-(9-Oxoacridin-10yl) Acetate;
NCIt definition : The sodium salt form of cridanimod, a small molecule that can increase progesterone
receptor (PR) expression, with potential antineoplastic adjuvant activity. Upon intramuscular
administration, cridanimod is able to induce the expression of PR in endometrial cancer.
This could increase the sensitivity of endometrial cancer cells to progestin monotherapy.
In combination with a progestin, cancer cells could be eradicated through increased
PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release
from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition
of estrogen release from the ovaries. This leads to an inhibition of cellular growth
in estrogen-dependent tumor cells. In addition, this agent is able to increase the
production and release of interferon (IFN) alpha and beta. PR is often downregulated
in endometrial cancer and makes it resistant to progestin-mediated hormone therapy.;
UNII : 54W868ROLR;
CAS number : 58880-43-6;
Drug name : Virexxa;
NCI Metathesaurus CUI : CL472224;
Origin ID : C114298;
UMLS CUI : C0891299;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
