Preferred Label : Opebacan;
NCIt synonyms : 132-L-Alanine-1-193-bactericidal/Permeability-increasing Protein (Human); rBPI 21; Recombinant BPI 21 Fragment; rBPI- 21;
NCIt definition : An injectable formulation composed of opebacan, a 21 kDa recombinant fragment of human
bactericidal/permeability-increasing protein (BPI), with potential anti-infective
activity. Upon intravenous administration, opebacan is able to mimic BPI and binds
to and neutralizes lipopolysaccharides (LPS or endotoxins), which are components of
the cell wall of gram-negative bacteria that induce a potent innate immune response.
This may prevent an endotoxin-mediated inflammatory response and may prevent graft-versus-host-disease
(GvHD) after myeloablative allogeneic hematopoietic stem cell transplantation (aHSCT).
BPI, a host-defense protein against microbial infection, is naturally produced by
neutrophils. Chemo- and radio-therapy induce neutropenia and depletion of endogenous
BPI. These therapies also cause intestinal damage and release of bacterial endotoxins
into the bloodstream, which initiate a systemic inflammatory response, activate donor
T-lymphocytes and possibly cause GvHD following aHSCT.;
UNII : 4X9EPQ6FMA;
CAS number : 206254-79-7;
Drug name : Neuprex;
NCI Metathesaurus CUI : CL471807;
Origin ID : C114296;
UMLS CUI : C3826891;
Semantic type(s)
- concept_is_in_subset
